From TV Animation: One Piece Grand Battle! 2 is a 2D versus fighting game similar to Super Smash Bros with 3D character models based on the One Piece anime and manga series and is the sequel to One Piece: Grand Battle!. The game offers a total of twenty-four playable character from the series up the Alabasta Arc and is very similar to its predecessor.

Each fighter has their own fighting techniques including special attacks and can run and jump on platforms in the various fighting arenas. Objects from (like barrels) the battlefield can be picked up and thrown at the opponent, these also contain power-ups. The twenty-four playable characters are: Monkey D. Luffy, Shanks, Roronoa Zoro, Sanji, Chopper, Dracule Mihawk, Smoker, Nami, Kuro, Mr. 2 Bon Kurei, Usopp, Tashigi, Arlong, Crocodile, Wapol, Vivi, Don Krieg, Mr. 3, Miss All Sunday, Karoo, Alvida, Buggy, Pandaman and Portgas D. Ace. Some of the character have supporting characters and others have to be unlocked like Ace.