NeoGeo Heroes: Ultimate Shooting is a shooting game with characters from different SNK franchises. The gameplay is similar to Space Invaders variants, each character has his own shooting style, the player can choose the rotate action horizontally or vertically and consists in 5 modes to play: Story mode: consists of 15 stages to beat, Challenge: consists to survive against bosses, Multi Play: to link other player via wireless connection, Sky Stage: Allows you to play KOF Sky Stage (the same than Story Mode but head to head like KOF), and Museum: To see the character profile information and artwork, listen sounds and music and see the score rankings.

This game includes those SNK characters: Kyo Kusanagi, Iori Yagami and Kula Diamond (from The King of Fighters series); Terry Bogard and Mai Shiranui (from Fatal Fury series); Athena Asamiya (from Psycho Soldier); Akari Ichijo (from The Last Blade series), Marco Rossi (from Metal Slug series); and Iroha (from Samurai Shodown VI).