Medal of Honor: European Assault is the latest addition to the Medal of Honor franchise. The story is set in Europe, in 1942. You are playing US Army Lieutenant William Holt, the first field agent of the newly formed Office of Strategic Services (OSS). Your role is to infiltrate enemy lines, destroy key documents and get rid of famous Nazi operatives.

The player leads a 3 man squad and can instruct their partners to take cover, attack enemies or retreat. Levels feature secondary objectives which can be completed in addition to the main objectives.